Defining Perineural Invasion

Perineural Invasion Prostate Cancer: A Deeper Dive

Defining Perineural Invasion

Perineural invasion (PNI) in prostate cancer occurs when the cancer cells spread from the prostate gland to a nearby nerve. This can be a concerning development as it suggests that the cancer may be more aggressive and challenging to treat.

Prognostic Significance

Studies have shown that PNI is associated with poorer clinical outcomes in prostate cancer patients. Specifically, it has been linked to: * Increased risk of biochemical recurrence * Higher likelihood of distant metastases * Reduced overall survival

Histopathologic Features

Under the microscope, PNI is characterized by: * Glomerulation: Cancer cells arranged in clusters around a nerve * Mucinous fibroplasia: Formation of mucin-producing cells around the nerve These pathognomonic features are indicative of PNI and can aid in diagnosis.