WEB Evans-Type Oxazolidinethione and Thiazolidinethione Auxiliaries
Introduction
Asymmetric catalysis has made significant progress in recent years, and chiral auxiliaries have played a vital role in this advancement.
Among the various auxiliaries, Evans oxazolidinones and their sulfur analogues are the most widely used. These auxiliaries have enabled the synthesis of a wide range of enantiopure compounds, including pharmaceuticals, natural products, and agrochemicals.
New routes to chiral Evans auxiliaries have been developed in recent years, including enzymatic desymmetrization and resolution. These new routes provide efficient and scalable access to these valuable chiral building blocks.
Conclusion
Evans-type oxazolidinethione and thiazolidinethione auxiliaries are powerful tools for asymmetric synthesis. These auxiliaries have made a significant contribution to the field of asymmetric catalysis, and they continue to be used in the synthesis of a wide range of enantiopure compounds.
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